Organization of the INIA
This INIA contains sixteen research components including twelve full-fledged U01 applications and four exploratory/developmental U01 applications. The research components focus on stress-alcohol interactions and excessive drinking from the molecular to the behavioral level in rodent and primate models. The research components are supported by four service core components that are essential to the well-ordered performance of the research.
Click on project hyperlinks for descriptions:
Administration: Stress-Anxiety of Alcohol Abuse, Kathleen A. Grant, P.I.(OHSU) Project 1: Robust Systems Genetics of Alcohol and Stress Effects on CNS, Robert Williams, P.I. (UTHSC) Project 2: Stress and Ethanol Self-Administration in Monkeys, Kathleen Grant, P.I. (OHSU) Project 3:Ethanol Dependence and Stress Effects on Ethanol Drinking: CRF & Neurosteroids, Howard Becker, P.I. (MUSC) Project 4:Early Stress & Alcoholism: Neurobiological Analysis, David P. Friedman, P.I. (WFUSM) Project 5:Stress, HPA Axis Dysfunction and Relapse in Alcoholism, Bryon Adinoff, P.I. (UTSMC) Project 6:Genomics Analysis of Social Stress and Individual Variation in Ethanol Drinking, Michael F. Miles, P.I. (VCU) Project 7: Ethanol, Stress and Dopamine, Sara R. Jones, P.I. (FUSM) Project 8:Ontological Discovery for Ethanol Research, Elissa Chesler, P.I. (JAX) Project 9: Social Isolation Stress: Role of Neurosteroids in the Action of Ethanol on GABAAR, Giovanni Biggio, P.I. (Univ. Calgiari) Bioinformatics Core - Informatics and Analysis Core, Michael F. Miles, P.I. (VCU) Knock-Out Core - Gene-Targeted Mouse Core, Eric Delpire, P.I. (Vanderbilt) Mouse Resources Core, Daniel Goldowitz, (UBC)Pilot Projects
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Schedule-induced polydipsia, stress, and ethanol drinking, Matthew
Ford, (OHSU)
Alcohol and Stress Regulation of NPY Signaling, Thomas Kash,
(UNC)
Chronic Alcohol-Induced Plasticity of the mPFC: Role for SK2
Channels, Patrick Mulholland (MUSC)
Hypothalamic opioid activity, PET opioid binding and alcohol
sensitivity, Elise Weerts (JHU)